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Utilization of the Organ Care System – A Game-Changer in Combating Donor Organ Shortage

Aron-Frederik Popov, Diana García Sáez, Anton Sabashnikov, Nikhil P. Patil, Mohamed Zeriouh, Prashant N. Mohite, Bartlomiej Zych, Bastian Schmack, Arjang Ruhparwar, Klaus Kallenbach, Pascal M. Dohmen, Matthias Karck, Andre R. Simon, Alexander Weymann

(Department of Cardiothoracic Transplantation & Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom)

Med Sci Monit Basic Res 2015; 21:29-32

DOI: 10.12659/MSMBR.894020

Published: 2015-03-12

ABSTRACT: For patients with end-stage heart failure, cardiac transplantation persists to be the gold standard. Nevertheless, the availability of organs remains a main constraint to the treatment. Through mounting usage of ex vivo heart perfusion an increase in organ availability was achieved by reconditioning of organs formerly not regarded as appropriate for transplantation. We propose the future standard application of this state-of-the-art technology to improve the pool of donor organs by evaluating hearts outside standard acceptability criteria.

Keywords: Heart Transplantation - methods, Graft Survival, Humans, Organ Preservation - methods, Perfusion - methods, Tissue Donors - supply & distribution