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Membrane Glycolipids Content Variety in Gastrointestinal Tumors and Transplantable Hepatomas in Mice

Jun Lv, Can Qun Lv, Bo-Liang Wang, Ping Mei, Lei Xu

(Department of Biochemistry, Wannan Medical College, Wuhu, Anhui, China (mainland))

Med Sci Monit Basic Res 2016; 22:87-90

DOI: 10.12659/MSMBR.899635

Published: 2016-08-24


BACKGROUND: The aim of this study was to investigate the variety of plasma contents of membrane glycolipids in 65 gastrointestinal tumors and 31 transplant hepatomas in mice.
MATERIAL AND METHODS: The experimental model was a transplantable murine hepatoma. Experimental mice were divided into 3 groups.
RESULTS: The LSA and TSA content in the 2 groups were significantly difference (p<0.01), and were significantly lower in the therapeutic group than in the control group (p<0.01).
CONCLUSIONS: These results indicate that membrane glycolipids index LSA and TSA are sensitive markers in gastrointestinal tumors. In the transplanted hepatomas in mice, they may be considered as ancillary indicators for judging the therapeutic effect of hepatoma.

Keywords: G(M3) Ganglioside, Intestinal Neoplasms, Membrane Glycoproteins, Stomach Neoplasms



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